Endocrine Abstracts

Introduction: The corticosurrenaloma is a rare malignant adrenal tumor with an unfavorable prognosis. The 5-year survival rate at stage IV, defined by the presence of distant secondary locations, does not exceed 28%. We report the case of a patient followed in our department for stage IV corticosurrenaloma and the challenges encountered during her managementCase report : Ms. H, a 42-year-old patient, is under our care for corticosurrenaloma. Her cancer w...

Introduction: Congenital hypogonadotropic hypogonadism (CHH) of hypothalamic or pituitary origin is a rare condition (1 in 5000 births). Clinical manifestations var, depending on the patient’s age and the severity, of the deficiency. CHH is often diagnosed in the context of delayed puberty, without impaired stature, typically, associated with tall stature.Patients and Methods: This is a bicentric study conducted at the Endocrinology Department of He...

Introduction: Congenital hypopituitarism is considered a study model to understand the mechanisms of development and the physiological functioning specific to the pituitary gland. Its exact prevalence is challenging to establish. In this report, we present the experience of the endocrinology department at Hedi Chaker University Hospital in Sfax regarding the diagnosis and management of patients with antehypopituitarism associated with growth hormone deficiency (GHD).<p cla...

Introduction: The pituitary stalk (PS) can be the target of various congenital or acquired pathologies. These conditions are increasingly encountered with the advent and development of magnetic resonance imaging (MRI). Clinically, PS pathology is often revealed by the occurrence of diabetes insipidus. However, other clinical manifestations related to hypothalamo-hypophysial involvement may also be variably associated.Objective: To identify the circumstan...

Background and Aims: Polycystic ovary syndrome (PCOS) may be the most common endocrine disorder in women of reproductive age. Most research findings suggest that PCOS is associated with eating disorders (ED). The aim of this research work is to study the eating disorders in women with PCOS.Methods: A cross-sectional study involved 172 women, 101 of them are Tunisian and 71 are French. Data collection was based on telephone interviews with Tunisian patien...

Introduction: Couple’s infertility is a major public health problem. Its prevalence is estimated at 15%. In half of the cases, this infertility is of male origin. Different etiologies may be involved, among which genetic abnormalities of the Y chromosome. In this context, we report the cases of two patients with a structural abnormality of the Y chromosome responsible for the abnormalities of spermatogenesisCase Description: The first 26-year-old ca...

Introduction: Myasthenia gravis (MG) is a chronic neuromuscular condition characterized by weakness in voluntary muscles. It is an autoimmune disorder. The emergence of the condition can be abrupt. As with any autoimmune disease (AID), it may be associated with other AIDs. We report a case of MG associated with Hashimoto’s thyroiditis (HT).Observation: The diagnosis of MG was established in a 58-year-old patient, based on the progressive onset of fa...

Introduction: Despite being organ-specific autoimmune diseases (AID), autoimmune thyroid diseases (AITD) may be associated with other AIDs either specific to other organs or systemic. These associations are not uncommon. They may be grouped in the form of an autoimmune polyendocrinopathy or multiple autoimmune syndrome (MAS). MAS is defined by the presence in the same person of at least three AIDs.Patients and Methods: It is a retrospective study over a ...

Introduction: Graves’ disease (GD) is an autoimmune disorder characterized by hyperthyroidism, and it often involves the development of Graves’ ophthalmopathy (GO). The latter occurs in a significant percentage (25-50%) of Graves’ disease cases. Active and severe ophthalmopathy can lead to a worsened prognosis and, in extreme cases, result in blindness. Reports about late ocular manifestation of GD have become scarce due to improved management.<p class="abst...

Introduction: Overt hyperthyroidism is the result of excessive production of thyroid hormones. The diagnosis is made on the basis of clinical characteristics and the diagnosis of certainty is made by hormone assay, combining low TSH with increased thyroid hormones. If the hyperthyroidism is left untreated, symptoms progress and can lead to complications that may jeopardize life prognosis.Patients and Methods: A retrospective study involving 29 patients w...